4-Thiazolecarboxylic acid
thiazole-4-carboxylic acid
CAS: 3973-08-8
Molecular Formula: C4H3NO2S
4-Thiazolecarboxylic acid - Names and Identifiers
| Name | thiazole-4-carboxylic acid |
| Synonyms | NSC 195467 4-Carboxy-1,3-thiazole Thiazole-4-Caxboxylicacid 4-Thiazolecarboxylic acid 1,3-thiazole-4-carboxylate thiazole-4-carboxylic acid 1,3-Thiazole-4-carboxylic acid 4-Thiazolecarboxylic acid 3973-8-8 1,3-Thiazole-4-Carboxylic Acid 3973-8-8 |
| CAS | 3973-08-8 |
| EINECS | 628-056-7 |
| InChI | InChI=1/C4H3NO2S/c6-4(7)3-1-8-2-5-3/h1-2H,(H,6,7)/p-1 |
| InChIKey | HMVYYTRDXNKRBQ-UHFFFAOYSA-N |
4-Thiazolecarboxylic acid - Physico-chemical Properties
| Molecular Formula | C4H3NO2S |
| Molar Mass | 129.14 |
| Density | 1.525±0.06 g/cm3(Predicted) |
| Melting Point | 195-199 °C (lit.) |
| Boling Point | 191 °C |
| Flash Point | 146.9°C |
| Solubility | DMSO (Slightly), Methanol (Slightly) |
| Vapor Presure | 0.000143mmHg at 25°C |
| Appearance | Solid |
| Color | White to Off-White |
| Maximum wavelength(λmax) | ['230nm(EtOH)(lit.)'] |
| pKa | 3.57±0.10(Predicted) |
| Storage Condition | 2-8°C |
| Physical and Chemical Properties | Thiazole-4-carboxylic acid is a colorless solid, m. P. 191 °c. Insoluble in water. |
4-Thiazolecarboxylic acid - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 43 - May cause sensitization by skin contact |
| Safety Description | 36/37 - Wear suitable protective clothing and gloves. |
| WGK Germany | 3 |
| HS Code | 29341000 |
| Hazard Class | IRRITANT |
4-Thiazolecarboxylic acid - Reference Information
| Use | Thiazol-4-carboxylic acid is an intermediate of the fungicide thiabendazole. Used as pharmaceutical and pesticide intermediates, organic synthesis reagents |
| Production method | The preparation method is to react formamide and P2S5 in ethylene glycol dimethyl ether (CH3OCH2CH2OCH3) to obtain thioformamide (HCSNH2), and then react with halogenated pyruvate to obtain the product. Formamide is added dropwise to P2S5 and dispersed in ethylene glycol dimethyl ether solvent at a temperature lower than 40 ℃ for about 30min. The reaction mixture is stirred at room temperature for 5h, and then methyl bromopyruvate is added dropwise to the above solution at 20~30 ℃ for about 1h, and then stirred for 3h at room temperature to obtain methyl thiazole -4-carboxylate, which is further hydrolyzed to obtain the product. |
Last Update：2024-04-09 20:52:54
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